SYNTHESIS OF NOVEL SERIES OF 2-AMINO-1, 2-DIHYDROISOQUINOLINE-3(4H)-ONE DERIVATIVES USED AS ANTIMICROBIAL AND ANTIOXIDANT AGENTSAbstract
A facile synthesis of novel 2-amino-1,2-dihydroisoquinoline-3(4H)-one and their amide derivatives (6a-o) through sydnone intermediate (3) was derived from tetrahydroisoquinoline-3-carboxylic acid (1) and various substituted phenyl acrylic acid derivatives (5a-o) in short reaction time with good yield. The structure of all novel synthesized compounds was established based on Mass, 1H NMR, 13C NMR, IR spectral data and Single crystal X-ray study (6e). All the synthesized compounds were evaluated for their antimicrobial and antioxidant activities.
Umamaheswari Mani *, Suresh Rathinasamy , Vadivel Kaliyamoorthy , Sridharan Rajagopal and Palathurai Subramaniam Mohan
Department of Medicinal Chemistry, Orchid Chemicals and Pharmaceuticals Limited, Plot No. 476/14, Old mahabalipuram road, Sholinganallur, Chennai 600 119, India.
12 April, 2014
04 July, 2014
30 July, 2014
01 November, 2014