SYNTHESIS OF POTENTIAL ANTI-INFLAMMATORY PYRAZOLINE DERIVATIVES UNDER ULTRASONIC IRRADIATIONAbstract
In the present investigation, the chalcone intermediates are synthesized by Claisen-Schmidt condensation reaction between acetanilide and appropriate aromatic aldehydes. Further, these chalcone intermediates were cyclized with phenylhydrazine in glacial acetic acid to give new pyrazolines derivatives using ultrasonic irradiation with higher yields in lesser time. All the synthesized derivatives are characterized by their TLC, Physical constant, FTIR, and 1H NMR. The Chalcone intermediates were screened for their antimicrobial activity while cyclized pyrazolines derivatives were screened in search of potential anti-inflammatory compounds. The compound 4c had shown good potential for anti-inflammatory activity.
J. P. Sethiya, S. P. Bhavsar and H. V. Shahare *
Department of Pharmaceutical Chemistry, SSDJ College of Pharmacy Chandwad, Nashik, Maharashtra, India.
03 November 2018
14 January 2019
18 January 2019
01 July 2019