SYNTHESIS OF SOME NOVEL OXADIAZOLE BASED CHALCONE DERIVATIVES AS ANTI-BACTERIAL AGENTSAbstract
A series of 1, 3, 4-oxadiazole derivatives were designed and out of which six compounds have been synthesized via four step synthetic scheme and evaluated for antibacterial activity using cup plate method. The compounds were previously characterized by IR, 1H-NMR spectral analysis. The compounds with hydroxyl and methoxy substituted phenyl rings showed higher activity than the chloro substituted derivatives and standard i.e vancomycin. The antibacterial study revealed that the most promising compounds are 3-(4-hydroxyphenyl)-1-(5-(2-hydroxyphenyl)-2-phenyl-1,3,4-oxadiazol-3(2H)-yl prop-2-en-1-one 6.4(a), 3-(4-methoxyphenyl)-1-(2,5-di phenyl-1,3,4-oxadiazol-3(2H)-yl)prop-2-en-1-one 6.4(b), 3-(4-hydroxy phenyl)-1-(2,5-diphenyl-1,3,4-oxadiazol-3(2H)-yl)prop-2-en-1- one 6.4(c), 3-(4-hydroxy phenyl)-1-(2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazol-3(2H)-yl)prop-2-en-1-one 6.4(e), 1-(2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazol-3(2H)-yl)-3-(4-methoxy phen yl)prop-2-en-1-one 6.4(f) against the tested bacteria (S. aureus, B. subtilis, P. aerugenosa, E. coli). This preliminary study revealed that these compounds may be used as potential leads for further studies.
P.K. Arora*, A. Mittal, G. Kaur, and A. Chauhan
Department of pharmacy, Lovely Professional University, Jalandhar, India
22 September, 2012
26 October, 2012
29 December, 2012
01 January, 2013