SYNTHESIS, SPECTRAL ANALYSIS AND BIOLOGICAL EVALUATION OF SOME NOVEL FLUROBENZOTHIAZOLE INCORPORATED 1, 3, 4 – THIADIAZOLEAbstract
A new series of flurobenzothiazole incorporated 1, 3, 4 – thiadiazole compounds have been synthesized. The structure of the synthesized compounds was confirmed by UV, IR, 1H NMR, Mass spectral analysis and evaluated for their antimicrobial activity against Proteus vulgaris NCTC 4635, Micrococcus leutus NL98, Aspergillus flavus ATCC 46646by disc diffusion method. The compounds SH8 and SH11 were also evaluated for the anti-inflammatory activity by carrageenan-induced paw oedema method. The synthesized compounds (SH6 to SH11) showed good antimicrobial activity. However the antimicrobial activity of the synthesized compounds against the tested organisms was found to be less than that of respective standard drugs used at tested dose level. The anti-inflammatory activity confirmed that the test compound SH11 showed superior activity in the inhibition of oedema than SH8. However, both the test compounds were found to be less active than the standard drug used.
M. Sugumaran* and R. Hemachander
Department of Pharmaceutical Chemistry, Adhiparasakthi College of Pharmacy, Melmaruvathur- 603 319, Tamil Nadu, India
24 February, 2012
29 March, 2012
24 May, 2012
01 June, 2012