TARGETING THE ENZYME – THE NEW TOOL FOR DRUG DELIVERYAbstract
Enzymes are the protein molecule that acts as a catalyst for various biological reactions. The enzymes have a major role in designing the dose of the drug. Enzymes have a vital role as metabolizer of the xenobiotic. The activity or the mode of action of enzymes determines the bioavailability of drugs. The presystemic metabolism of the drug monitored by the gut wall and hepatic enzymes can increase or decrease the bioavailability. The drastic presystemic metabolism of the drug may reduce the amount of the drug reaches into the systemic circulation. Means enzymes are one of the keys that control the therapeutic action. It can be assumed that an increase in drug concentration followed by an oral administration of the drug can be achieved by inhibiting the metabolizing enzymes. A study has been conducted on this which claims so many therapeutic applications of enzyme inhibition. The principle of enzyme inhibition can be used for treating various diseases like mammary cancer various infectious diseases and even for chemoprevention. The enzyme inhibition achieves a greater increase in the bioavailability of drugs. Thus, inhibiting the metabolizing enzyme can be an optional pathway for enhancement of bioavailability by reducing the dose dumping. The chance of developing the drug resistance can be reduced, and ADR can be properly monitored.
D. Joseph * and S. R. Suseem
School of Advanced Sciences, Vellore Institute of Technology, Chennai, Tamil Nadu, India.
30 May 2018
02 September 2018
20 September 2018
01 February 2019