THE POTENTIAL ROLE OF FLAVONOIDS IN THE CONTROL OF OXIDATIVE STRESS FOR TYPE II DIABETESAbstract
Introduction: Antioxidant properties of flavonoids may guard against oxidative damage to cells, DNA, or lipids. The ample literature about flavonoids can affirm the structural and pharmacological cherishing of this class of phytochemicals. The presence of aromatic rings in the flavonoid molecule consent the receiving and donation of electrons from free radical species, which abets to curb the free radicals. Methodology: This is a prospective observational study conducted on diabetic patient’s over-period of one year in the outpatient department of a tertiary care teaching Hospital. Red blood cells (RBC) were separated from the 20 ml of blood samples, which have been collected from the 90 subjects. The collected RBC were divided into four equal parts for which superoxide dismutase, catalase, and glutathione peroxidase activity was estimated with and without the flavonoids. The absorbance was recorded in a spectrophotometer. Results and Discussion: The results symbolize a significantly higher superoxide dismutase, catalase, and glutathione peroxidase activities for quercetin than kaempferol and chrysin. Quercetin is more effective on Superoxide dismutase followed by kaempferol and chrysin. But there were no statistically significant differences between catalase and glutathione peroxidase values obtained in the three diabetic samples. Conclusion: The present investigation revealed that all the flavonoids (quercetin, chrysin, and kaempferol) have potent antioxidant activity. The results affirmed that quercetin, kaempferol, and chrysin amplified the antioxidant activity in-vitro. It may be a possible mechanism to marsh diabetes coupled with complications.
S. R. Nelli *, N. K. Sharma, P. M. Kumar and S. S. Singh
Cancer and Translational Research Lab, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
17 November 2018
09 March 2019
04 May 2019
01 August 2019