THE THERAPEUTIC POTENTIAL OF FRESH GOAT’s MILK AGAINST PREMATURE OSTEOPOROSIS BY INHIBITING OF BIOMARKERS OF BONE RESORPTION IN UNTRAINED HEALTHY WOMENAbstract
The aim of this study was to (1) analyze the effect of fresh goat’s milk intervention on serum Carboxyterminal Cross-Linked Telopeptide of type I Collagen (CTX) and calcium in untrained healthy women, therefore goat milk can be used for osteoporosis therapy, (2) examined the relationship between levels of calcium and CTX after the intervention of fresh goat’s milk. The research design was a controlled randomized trial. Eighteen volunteers sedentary women were randomized into 2 equal groups (control, n=9, and trial, n=9), aged 18-19 years, healthy, and did not consume high calcium foods or drugs. The treatment group was treated with 250 ml/day of fresh goat’s milk, given in the morning, for 110 days. Fasting morning serum calcium and CTX levels were measured before and after fresh goat milk intervention. The data were analyzed by the statistical t-test and linear correlation with the significance level of 5%. Untreated, both serum calcium and CTX levels in the trial and control group were not significantly different (p>0.05). Treated, serum calcium levels were higher (p<0.05) in the trial group than the control group. Serum CTX levels were lower (p<0.05) in the trial group than in the control group. There was a significant increase in calcium levels and the significant decrease of CTX levels after-treated in the trial group. Goat milk affects inhibiting the process of bone resorption in untrained healthy women.
Y. Yusni *, S. Syahrul, S. Rahman and R. S. Siregar
Department of Physiology, Faculty of Medicine, Syiah Kuala University, Banda Aceh, Aceh, Indonesia.
12 August 2018
19 October 2018
23 October 2018
01 April 2019