TREATMENT WITH ORAL METAFOL L APPEARS TO PROMOTE RESTORATION OF LOST CUTANEOUS SENSATION IN DIABETIC PERIPHERAL NEUROPATHYAbstract
The purpose of this research work is to determine whether Metafol-L improves sensory neuropathy in patient with Type 2 diabetes or not. In patients with diabetes mellitus, prolonged hyperglycemia can result in peripheral neuropathy (pain and/or loss of sensation in the extremities). Neuropathy issues may be related to Vitamin B deficiencies; therefore, the supplementation of Vitamin B12, Vitamin B6, and folate (Vitamin B9) may improve diabetic peripheral neuropathy (DPN). Metafol L is a product containing L-methyl folate, pyridoxal 5 phosphate, and methylcobalamine for management of endothelial dysfunction. Metafol-L ingredients counteract endothelial nitric oxide synthase uncoupling and oxidative stress in vascular endothelium and peripheral nerve. Studies of monotherapy with l-methylfolate, methylcobalamine and pyridoxine 5 phosphate suggest that each of these bioavailable B vitamins may reverse the pathophysiology and symptoms of DPN. After approximately six month of treatment, patient undergoes follow up biopsy. At the end of their treatment 79% of patient showed an increase in calf ENFD & 87% of patient show experienced both reduced frequency and integrity of paraethesias and or dysesthesias.
Pallavi Shende * and Sudarshan S Joshi
Department of Pharmaceutics, Allana College of Pharmacy, University of Pune, Maharashtra, India.
14 December, 2016
09 February, 2017
17 February, 2017
01 July, 2017