TYPICAL PHYSICAL ATTRIBUTES OF MICROCRYSTALLINE CELLULOSE DRIED BY SPRAY, SPIN FLASH AND BULK DRIER AND THEIR RESULTANT EFFECTS ON TABLET PROPERTIESAbstract
The solid dosage form is the easiest method of administering drugs for systemic effect. All dosages forms are made by two main components one is API and second is excipient. Excipient is present in bulk quantity and is required for binding the API. There are mainly two techniques uses for manufacturing the tablets (i) wet granulation (ii) direct compression. Wet granulation is a time consuming process, and direct compression technique is time saving, cheap and convenient for pharmaceutical industries. In direct Compression technique, microcrystalline cellulose powder properties are very versatile. There are many processes used for drying of MCC. Out of these, we evaluated MCC with three different type of drying process i.e. Spray dried (SPD), spin flash dried (SFD) and bulk dried. Different drying methods do not change the chemical parameters of microcrystalline cellulose, only difference being the physical attributes of the MCC powder, it’s morphology and it’s consequents flow properties which directly effect the tablet properties i.e. compaction, hardness and in-vitro disintegration among others.