U.V SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF MESALAZINE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORMSAbstract
Mesalazine is used, either orally or rectally, as an anti-inflammatory agent in treating ulcerative colitis and, to a lesser extent, Crohn’s disease. Mesalazine is a white to pinkish crystalline powder. It is slightly soluble in cold water and alcohol; more soluble in hot water, soluble in hydrochloric acid. A simple UV spectrophotometric method was developed for the determination of Mesalazine (MEZ) in pure and its pharmaceutical formulations. Mesalazine exhibiting max absorbance at 210 nm in methanol and obeyed linearity in the concentration range of 0.2-50 mg/ml. The proposed method was statistically validated.
Rakesh Kumar Singh*, Pankaj Singh Patel and Pragya Gupta
College of Pharmaceutical Sciences *, Mohuda, Berhampur, Orissa
20 January, 2010
15 February, 2010
24 February, 2010
01 March, 2010