UNCOMMON SIDE EFFECTS OF COMMONLY USED ANTI-DIABETICS: TIME TO MONITOR THEMAbstract
Diabetes, a chronic endocrine metabolic disorder, is managed using several anti-diabetic medications. Being a chronic disease requiring lifelong medications, the long-term safety profile and patient acceptance are crucial to achieving therapeutic success. The available medications are known to have common side effects such as hypoglycemia, weight gain, and gastrointestinal adverse effects. Uncommon adverse effects, although rare can be troublesome in some patients and may lead to decreased medication adherence/concordance and hence treatment failure. There are reports of metformin being associated with lactic acidosis and sulfonylureas with cholestatic jaundice. Piogliatazone can have a rare adverse effect of pulmonary edema with or without congestive heart failure. Acarbose can be the reason for ileus and sub ileus in patients. Glucagon-like peptide-1 receptor agonists like liraglutide can cause pancreatitis. Careful consideration of anti-diabetics while prescribing, adequate clinical and laboratory monitoring and proper counseling of patients might help in prevention and early detection of these rare but severe adverse effects of anti-diabetics.
G. S. Mohiuddin *, S. Palaian, P. R. Shankar, K. G. Sam and M. Kumar
Department of Pharmacy Practice, College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates.
30 December 2018
10 July 2019
13 August 2019
01 September 2019