UV DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF METAXALONE AND DICLOFENAC POTASSIUM IN COMBINED DOSAGE FORMAbstract
A Simple, Fast and Reliable UV Derivative Spectrophotometric Method was developed and Quantitative Estimation of Metaxalone and Diclofenac potassium in Pharmaceutical Dosage Form was carried out using the First Derivative values measured at 276 nm for Metaxalone and 270 nm for Diclofenac potassium. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Metaxalone using 80-800 µg/ml and 10-100 µg/ml of Diclofenac potassium for First Derivative Spectrophotometric Method and the correlation coefficient was found to be 0.9986 and 0.9982 respectively. Precision study showed that the % RSD was within the range of acceptable limits (< 2), and the % Recovery was found to be in the range of 99-100% for Metaxalone and 100-101% for Diclofenac potassium. Developed Spectrophotometric Method in this study was Simple, Accurate, Precise, Specific, Sensitive, Reproducable and can be directly and easily applied to Pharmaceutical Dosage Form.
B. Ramya*, K. Vinod Kumar, P. Ramalingam and J. Ravindra Reddy
Division of Pharmaceutical Analysis and Quality Assurance, Center for Pharmaceutical Research (CPR), Raghavendra Institute of Pharmaceutical Education and Research (RIPER), K.R. Palli cross, Chiyyedu (Post), Anantapur-515 721, Andhra Pradesh, India
16 July, 2012
15 September, 2012
29 October, 2012