VALIDATED KINETIC SPECTROPHOTOMETRIC DETERMINATION OF DRUGS USING ALKALINE POTASSIUM PERMANGANATE OXIDATIONAbstract
A simple and sensitive kinetic method is described for the determination of drugs viz., Bendamustine hydrochloride (BEN), Ciprofloxacin hydrochloride (CIP), Dorzolamide hydrochloride (DOR), Pantoprazole sodium (PAN), Warfarin sodium (WAR). This method is based upon a kinetic investigation of drug oxidation with alkaline potassium permanganate. Kinetics of the oxidation reaction is followed spectrophotometrically, as one of the reaction product, Mn (VI), absorbed at 610 nm. All variables affecting color development have been investigated and the conditions optimized. Among the methods applied were the Initial rate and fixed-time methods. Accounting for the applicability, the sensitivity, values of correlation coefficient (r) and intercept (a), the Fixed-time method is selected for these five drugs assay. The absorbance-concentration plots were rectilinear within the range of 8.5-51 µg.mL-1 for BEN 1-6 µg.mL-1 for CIP, 10-60 µg.mL-1 for DOR 20-120 µg.mL-1 an7-42 µg.mL-1 for WAR. The statistical data for the results challenged for the robustness of the fixed-time method.
M. Prashanthi and G. Venkateshwarlu *
Department of Chemistry, Osmania University, Hyderabad, Telangana, India.
22 September 2018
04 December 2018
14 December 2018
01 June 2019