VASORELAXANT AND ANTIHYPERTENSIVE EFFECTS OF RHUS PENTAPHYLLA (SEARSIA PENTAPHYLLA)Abstract
Rhus pentaphylla (Jacq.) Desf. (Searsia pentaphylla (Jacq.) FA. Barkley) is used for its colorant and tanning properties by the local population. The bark, leaves, roots, and fruits are employed in Moroccan traditional medicine to treat gastrointestinal disorders and diarrhea. Nevertheless, the pharmacological properties of R. pentaphylla on cardiovascular diseases have not yet been presented. This study was carried out to explore the vasorelaxant effect of the aqueous extract (decoction) from the leaves of R. pentaphylla (RpAE), its mechanism of action, and its antihypertensive effect. The results of this study demonstrate that RpAE induces a dose-dependent effect on isolated rat aorta. The vasorelaxation is endothelium-dependent via the muscarinic receptor, Calmodulin/eNOS/sGC/cGMP/PKG signaling pathway through the activation of SERCA pump, the inhibition of VOCC, and opening of KCa2+ channels. In-vivo, RpAE induces antihypertensive effect, ameliorates diuresis, and vascular reactivity on L-NAME induced hypertensive rats. The oral administration of RpAE reveals no mortality or toxicity. This is the first study in Morocco showing vasorelaxant and antihypertensive effects of species belonging to genus Rhus.
N. Messaoudi, H. Mekhfi, M. Aziz, A. Legssyer, M. Bnouham and A. Ziyyat *
Laboratory of Physiology, Genetics and Ethnopharmacology, Department of Biology, Faculty of Sciences, University Mohammed First, Oujda-Morocco.
16 January 2019
03 May 2019
13 June 2019
01 October 2019