XANTHAN GUM GRAFT COPOLYMER / SODIUM ALGINATE MICRO BEADS COATED WITH CHITOSAN FOR CONTROLLED RELEASE OF CHLORTHALIDONE DRUGAbstract
In the present work, temperature/pH-sensitive copolymer beads of chitosan (CS) coated sodium alginate/xanthan gum grafted N, N’-methylenediacrylamide have been synthesized by free radical polymerization in an atmosphere of nitrogen using AIBN/Fe2+ redox pair initiator and Tetramethylethylenediamine (TEMED) as a catalyst followed by simple ionotropic gelation technique. These beads were characterized by Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), Field emission scanning electron microscopy (FESEM) Energy-dispersive X-ray spectra (EDS) and X-ray diffraction measurements (X-RD). DSC and X-RD studies reveal the molecular dispersion of Chlorthalidone (CT) drugs. Swelling and drug release behaviors of these beads were investigated in simulated intestinal fluid (pH 7.4) and gastric fluid (pH 2.0) at 37 ºC. Results illustrated that both the swelling and degradation of the optimized beads were influenced by the pH of the test medium, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into the Korsmeyer-Peppas equation.
T. Jithendra, O. S. Reddy, M. C. S. Subha *, C. Madhavi and K. C. Rao
Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, Andhra Pradesh, India.
07 May 2019
12 January 2020
29 January 2020
01 March 2020