COMPARATIVE STUDY OF FORMULATED WOUND HEALING OINTMENTS WITH THE MARKETED PRODUCT BY IN-VIVO METHOD

A wound is a breakthrough of skin; it disrupts the normal functioning of skin. So, the wound healing process is important to repair the skin. It restores the normal function and structure of the skin. There are several phases of the wound healing process: inflammation, re-epithelization, vascularization, and granulation tissue formation and maturation. The wound healing process can be studied using in-vitro and in-vivo methods. There are many in-vivo methods to study the wound healing process. In-vivo method uses laboratory animals for the study. Animals used are mice, rats, rabbits, and pigs. Recently, Zebrafish have been used as a model to study the wound healing process. Zebrafish are used because it has similar wound closure properties as mammalian embryos. The wound healing can be studied by amputating the caudal fin of fish and recording the regeneration of the fin on days 5th, 7th and 9th post-amputation. This study compares various wound healing agents with the market product (neomycin cream). The various wound healing agents used in this study are pomegranate peel powder, Aloe vera powder, potash alum powder, lavender oil, and sesame oil. The wound-healing effects of these agents are studied using Zebrafish as an in-vivo wound-healing model.