IN-VITRO PHOTOPROTECTIVE EFFECT OF AN ACTINOMYCETE DERIVED MELANIN AGAINST MELANOMA
AbstractActinomycetes are biotechnologically important microorganism as they produce many secondary metabolites and natural pigments, including a dark-brown pigment melanin. Melanin is produced in melanocytes that provides pigmentation to skin. Although many roles have been attributed to melanic pigments, the main role in nature seems to be photoprotection damage. Melanin possesses anti- UV radiation property by absorbing the electromagnetic spectrum and preventing optical damage in the living organisms. Melanoma is a malignant of melanocytes that controls the pigment melanin in the skin. The aim of the present study is to isolate the melanin producing actinomycetes from the agricultural soil and to assay the cytotoxicity using murine B16 melanoma cell line and normal mouse L929 fibroblast cell line. The results showed that the melanin obtained from the actinomycetes showed good anticancer activity against murine B16 melanoma cell line and nontoxic against normal mouse L929 fibroblast cell line. Hence it can be used as a photoprotective agent.
Article Information
38
5909-5915
1990 KB
222
English
IJPSR
E. Devika, S. Gayathri, V. Swarnalakshmi and A. Vidhya *
Department of Microbiology, D. K. M. College for Women, Vellore, Tamil Nadu, India.
vidhyasur76@gmail.com
30 April 2023
06 July 2023
28 July 2023
10.13040/IJPSR.0975-8232.14(12).5909-15
01 December 2023
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