FORMULATION AND EVALUATION OF SUSTINED RELEASE MATRIX TABLET OF METRONIDAZOLE
AbstractIn this study matrix tablets of metronidazole were prepared by direct compression method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Six formulations of different polymer percentages were formulated (F1-F9). The mean hardness values were measured for all the formulation using Monsanto hardness tester. The hardness value ranges from 5.2±0.2 to 5.8±0.1kg/cm2. Twenty tablets were randomly selected from each formulation and evaluated. The obtained data were almost uniform. The values of tablets average weight ranging from 549±5 to 558±7mg. All the tablets passed weight variation test as the % weight variation was within the USP Pharmacopoeia’s limits of ±5% of the weight. The % drug content of all the formulated tablets were found within the limit. % Drug content value of drug was within 98.12±0.25% to 99.85±0.18%. The results within the range indicate uniform of mixing. When the regression coefficient values compared, it was observed that ‘r2’ values of first order was maximum i.e., 0.937 hence indicating drug release from formulations was found to follow first order release kinetics.
Article Information
51
6029-6037
774 KB
477
English
IJPSR
Ravindra Kumar Shah and Gopal Patel *
Sagar Institute of Pharmacy and Technology, Gandhi Nagar Campus Opposite International Airport, Bhopal, Madhya Pradesh, India.
gopal87patel@gmail.com
04 September 2022
08 August 2023
11 November 2023
10.13040/IJPSR.0975-8232.14(12).6029-37
01 December 2023
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