LIQUISOLID TECHNIQUE: A NOVEL APPROACH FOR SOLUBILITY ENHANCEMENT

Liquisolid Technique is one of the novel approach for drug delivery system for oral route. Bioavailability of any drug is mainly dependent upon its dissolution rate and dissolution rate is dependent upon solubility of that drug. So, if any drug has less solubility then of course its bioavailability will be less. Hence there is need of enhancement of solubility of poorly soluble drugs for enhancing their bioavailability. There are various methods which are used for enhancing bioavailability of poorly soluble drugs like micronization, nanonisation, supercritical fluid recrystallisation, spray freezing in to liquid, use of surfactants, use of salt forms, pH adjustment, solid dispersion, chemical modification, micellar solubilization.etc. Nowdays liquisolid technique is used as one of the method for enhancing solubility of poorly soluble drugs. Liquisolid technique is also called as ”Powdered Solution Technology” In this technique liquid drugs or drug suspensions or solutions of water insoluble solid drugs in suitable nonvolatile solvent system into non adherent, freely flowing, readily compressible powder by blending it using suitable carrier material and coating material. It is also used as a best alternative for soft gelatin capsules.