EVALUATION OF ANTIRETROVIRAL TDDS CONTAINING NATURAL PENETRATION ENHANCER

Aim: This study aims to explore the potential of transdermal drug administration as a viable alternative to conventional medication delivery systems. Specifically, the focus is on the development and evaluation of transdermal patches containing Lamivudine and Stavudine for the treatment of AIDS. The overarching objectives include extending drug release duration, reducing administration frequency, and enhancing patient compliance. Material & Methods: The formulations under investigation are meticulously designed using a combination of HPMCK15M, PVPK30, and EC in varying ratios. The patches are subjected to a thorough assessment, encompassing critical parameters such as film thickness, tensile strength, and drug content homogeneity. The incorporation of Tween 80 and dimethyl sulfoxide as plasticizer and penetration enhancer is a key methodological consideration for optimizing the transdermal patches. Additionally, the study explores the impact of natural permeation enhancers, such as oleic acid, eucalyptus oil, and clove oil, on drug permeation and release kinetics. Results: The outcomes of the study reveal promising findings, with the transdermal patches exhibiting favorable characteristics, including optimal film thickness, tensile strength, and uniform drug content. The use of Tween 80 and dimethyl sulfoxide as plasticizer and penetration enhancer proves effective in enhancing patch properties. Furthermore, the incorporation of natural permeation enhancers demonstrates a significant impact on drug permeation, with a notable achievement of zero-order kinetics in drug release. These results underscore the potential of transdermal drug delivery to address limitations associated with traditional dosage forms, offering a novel and promising approach for enhanced bioavailability and improved patient outcomes in the context of AIDS treatment.