FORMULATION AND IN-VITRO EVALUATION OF BUPROPION HYDROCHLORIDE CONTROLLED RELEASE TABLET
AbstractThe aim of the study was to develop and evaluate matrix based controlled drug delivery system of Bupropion hydrochloride. Controlled release tablets were prepared by employing Guar gum, Eudragit RS 100, HPMC K15M, HPMC K100M at different concentration. All 13 batches passed friability, hardness, weight variation, assay but only four batches (CRB7W, CRB8W, CRB10W, and CRB11W) passed the dissolution as per USP 30 NF25 for extended release tablet of Bupropion hydrochloride. Among the four formulation CRB7W & CRB11W follows Higuchi Model and CRB8W & CRB10W follows First order model. The optimized formulations were compared with the marketed product for similarity and dissimilarity factor. CRB7W and CRB10W showed dissimilar result and CRB8W and CRB11W showed similar result with marketed product. HPMC (K15M 7& K100M) as a matrix polymer used in tablet formulation provide a good initial retardation in the release as well as helped to enhance the overall release rate of the drug than that of Gaur gum and Eudragit RS 100.
Article Information
23
2783-2790
581
2928
English
IJPSR
Anjan Paudel*, Subash Tha Shrestha, Yogendra Raj Pandey and Sumit Chandra Shrestha
Faculty of Pharmacy, Asian College for Advanced Studies, Purbanchal University, Lalitpur, Nepal
phranjanpaudel@gmail.com
21 January, 2014
12 March, 2014
05 April, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(7).2783-90
01 July, 2014
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