ACUTE AND SUB ACUTE TOXICITY STUDY ON SIDDHA DRUG RASA CHENDOORAM
AbstractHerbal and herbo mineral preparations are being traditionally used in Indian system of Medicine especially in Siddha Medicine. Herbo mineral preparations have longer Shelf life. Rasa Chendooram (RC) is prepared as per classical text book of Prana Rakshamirtha Sindhu, for Vadha diseases. Before conducting clinical trial, Pre clinical study should be undergone as per WHO guidelines .The clinical trial has been approved by IEC (IEC NO-GSMC-CH/1/2013/011).The present preclinical study aims to carry out safety and toxicity of RC (IAEC NO.XXXXIX/07/CLBMCP/2013dated 29.06.2013) Adult both sex of Swiss albino rats weighing 220-250 gm were used. Acute & Sub acute toxicity were carried out as per OECD guidelines 423 and 407. Hematological Parameters, biochemical parameters histopathological study were performed for all animals. The study concludes that on oral administration of 100mg/kg of bodyweight of RC to Swiss albino rats, there was no change in behaviour movements and no characteristic clinical sign of toxicity or mortality observed.
Article Information
52
5463-5468
972KB
1532
English
IJPSR
M. Jayabharathi *, M. Mohamed Mustafa and P. Sathiyarajeswaran
Post.Graduate Scholar Sirappu Maruthuvam Dept. GSMC, Chennai. Tamil Nadu.India.
bharathivelan84@gmail.com
07 May, 2014
26 July, 2014
18 August, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5463-68
01 December 2014
Download