FORMULATION AND EVALUATION OF MUCOADHESIVE GEL FOR ORAL CANDIDIASIS

Oral candidiasis (OC) is a common fungal infection characterized by white patches on the oral mucosa, often triggered by factors like immunosuppression and medication use. It can affect anyone, regardless of age or background. The formulation of mucoadhesive gels for the treatment of oral candidiasis is a promising area of research. The gel enhances the residence time of the drug at the site of infection, thereby improving therapeutic efficacy. This study aimed to develop a mucoadhesive gel for oral candidiasis treatment using an inclusion complex of itraconazole and beta-cyclodextrin. Different concentrations of mucoadhesive polymers (Carbopol 940) and absorption enhancers (Poloxamer 188 and propylene glycol) were used. The pH of the gels ranged from 6.5 to 7.2. The viscosity varied between 300 and 600 cps. The gelation temperature was 30°C to 35°C. Spreadability ranged from 4.7 to 4.83 cm. The drug content was found to be 90% to 95%. Mucoadhesive force ranged from 3549 to 3917 dyne/cm². Drug release lasted 6 hours, with 95 to 99% cumulative release. In-vitro antifungal activity showed a zone of inhibition of 10 to 15 mm against Candida albicans. The mucoadhesive gels exhibited favourable physicochemical properties and demonstrated potential for oral candidiasis treatment and therapeutic efficacy for treating oral candidiasis.