REMARKABLE ANTI-TRYPANOSOMA CRUZI ACTIVITY IN SELECTED SALVADORAN PLANT SPECIES
AbstractIn Latin America, Chagas is one of the most prevalent diseases, and current chemotherapy with benznidazole and nifurtimox is ineffective in chronic phase. Therefore, the development of new drugs, especially for the chronic stage of the infection, is urgently needed. Performing an in-vitro anti-trypanosome assay, we analyzed 114 plant species from Salvadoran flora, resulting in 34 active plants against epimastigote of Trypanosoma cruzi belonging mainly to the botanical families Piperaceae, Asteraceae, Salicaceae, Annonaceae, and Acanthaceae. Thus, nine of them showed prominent activity between 91.18 to 98.94% of viability suppression at 100 µg/mL (Annona holosericea, Calea urticifolia, Eremosis leiocarpa, Peperomia pseudoalpina, Piper amalago, Piper martensianum, Casearia corymbosa, Piparea dentata and Solanum nudum), highlighting C. corymbosa, P. pseudoalpina and P. martensianum as the most promising species as sources of natural compounds useful for the treatment of Chagas disease. P. speudoalpina and P. martensianum do not have reports of their phytochemical composition or biological activities.
Article Information
17
1308-1317
856 KB
53
English
IJPSR
U. G. Castillo, K. Alas, M. Mejía, G. Cerén, W. D. Castro-Godoy, R. M. Guerrero, J. Menjívar, M. L. Martínez, C. E. Arias, J. Nakajima-Shimada and M. J. Núñez *
Laboratorio de InvestigaciónenProductos Naturales (LIPN), Facultad de Ciencias Naturales y Matemática, Universidad de El Salvador, San Salvador Centro 1101, El Salvador.
marvin.nunez@ues.edu.sv
12 December 2024
07 January 2025
07 January 2025
10.13040/IJPSR.0975-8232.16(5).1308-17
01 May 2025
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