CARBOPROST: A PROMISING PREVENTIVE APPROACH FOR THE POSTPARTUM HAEMORRHAGE

Background: Childbirth is a multi-stage process, and the postpartum period holds significant implications for maternal health. The third stage of labour, when the placenta detaches, is the most dangerous for women because of excessive bleeding (postpartum hemorrhage or PPH). This is often caused by the uterus not contracting properly (uterine atony). Thus, there’s a well-established practice called active management of the third stage that helps to prevent these complications. Objectives: To assess the efficacy and safety of carboprost in active management of third stage of labour. Methodology: Sixty parturient were enrolled in a study. Following the delivery of the baby’s anterior shoulder, these parturient received a single intramuscular injection of 125 microgram of carboprost. The primary outcomes assessed were the duration of the third stage of labour, the amount of blood loss, and the incidence of postpartum hemorrhage (PPH) Results: This study group experienced an average third stage of labor duration of 5.25 ± 1.73 minutes, accompanied by an average blood loss of 157.41 ± 49.43 ml and the need for additional uterotonics was minimal. Conclusion: Our study concludes that Carboprost, adose of 125 microgram exhibits a promising uterotonic profile, indicating its potential suitability as a prophylactic medication within active management protocols for the third stage of labour. Further investigation is necessary to confirm this potential benefit.