NANO SILVER INFUSED ANTIFUNGAL UNDERGARMENT: DEVELOPMENT, CHARACTERIZATION, AND CLINICAL EVALUATION

Background: Fungal infections, particularly dermatophytosis, affect nearly one-fourth of the global population, with Tinea cruris being prevalent in humid climates. Silver nanoparticles (AgNPs) exhibit strong antimicrobial particularly antifungal properties and may offer an effective textile-based solution. This study aimed to develop, characterize, and clinically evaluate nanosilver-infused antifungal undergarments to combat recurrent Tinea cruris. Methods: A 95% cotton and 5% elastane fabric blend was treated with a 0.3% nanosilver suspension using the exhaust method. Characterization involved scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) to assess nanoparticle deposition. Wash durability was evaluated over 30 cycles. Antimicrobial activity was assessed using AATCC 100:2019 for antibacterial efficacy against Staphylococcus aureus and Klebsiella pneumoniae and AATCC Part 3:2017 for antifungal activity against Candida albicans. A prospective, real-world evidence, experimental clinical study was conducted on 90 patients with recurrent tinea cruris who wore nanosilver-infused innerwear for twelve weeks alongside standard antifungal treatment. Clinical outcomes were assessed at four and twelve weeks. Results: SEM-EDX confirmed the successful deposition of AgNPs, while XRD analysis indicated crystalline stability. Wash durability testing demonstrated consistent nanoparticle retention. Antimicrobial assays showed significant bacterial and fungal growth inhibition. Clinically, patients exhibited improved symptom resolution and reduced recurrence rates. Conclusion: Nanosilver-infused fabric exhibits strong antifungal properties, offering a promising adjunct to conventional antifungal therapy for managing recurrent Tinea cruris. Their durability through multiple washes and patient benefits highlights broader dermatological applications. This approach may enhance treatment efficacy and reduce reinfection rates. Further large-scale studies are needed.