SOPHISTICATED INSTRUMENTAL ANALYSIS OF NOVEL SIDDHA FORMULATION NAVAMANI CHENDURAM THROUGH MODERN TECHNIQUES

Navamani Chenduram (NC) is one of the metallic preparations mentioned in the classical Siddha literature “Sikitcha Rathina Deepam” which is indicated mainly to treat female reproductive diseases like amenorrhea, ovarian tumor and ascites. Preparing the Trial drug in accordance with the standard operating procedure and put through a number of studies to ensure its safety, effectiveness, purity, and quality. WHO has highlighted the necessity of employing contemporary methods to guarantee quality control of Indian medicines. The aim of the study was to standardize the NC through Sophisticated instrumentation techniques like Inductively Coupled Plasma – Optical Emission Spectroscopy (ICP-OES), Fourier Transform Infra-Red (FTIR), Scanned Electron Microscopy with Energy Dispersive X-Ray Analysis (SEM EDAX) and X-ray Diffraction (XRD) for the detection of Functional group, Chemical, Elemental analysis, Particle size, Heavy metals analysis and Minerals present in NC. Also identified the drug substance forms and determine its molecular structure. The results showed that under ICP OES Heavy metals like Aluminum, Arsenic, Copper, Magnesium, and Mercury were found below the detection level. The stretches and bonds present in the FTIR analysis indicates that the presence of functional groups Amide, Phenols and alcohols, Alkanes, Aldehyde, Amine, Alkenes, Alkanes, Ester, Alkyne which may be the reason for the therapeutic potency of the drug. SEM EDAX analysis indicated the existence of nanoparticles. XRD results revealed the good crystallinity after calcinations process. Therefore, it seems an evident that the safety of NC has been validated using modern scientific method.