PREPARATION AND EVALUATION OF CYCLODEXTRIN COMPLEXATION OF ETORICOXIB
AbstractCyclodextrin complexes of etoricoxib (poorly water soluble COX-2 inhibitor) were prepared with the β-CD and HPβ-CD by different techniques (physical mixture, kneading and co-evaporation methods) at 1:1 and 1:2 molar ratios. Characterization of the complexes was done in solution by phase solubility analysis and in solid state using FTIR. The stoichiometry and stability constants of ECB-β-CD (1:1-200.4 M-1) and ECB-HPβ-CD (1:1-166.94 M-1) complexes were calculated by phase solubility method. Remarkable improvement in in-vitro drug release profiles in distilled water was observed with all complexes, especially with those prepared by kneading method than with physical and co-evaporation methods. HPβ-CD gave highest enhancement in the dissolution rate of ECB. Thus, it is concluded that stable and dissolution improved CD complexes can be prepared for etoricoxib with β-CD and HPβ-CD.
Article Information
55
4938-4944
732
1252
English
Ijpsr
Mettu Srikanth Reddy* and N. G. Raghavendra Rao
Department of Pharmaceutics, Jyothishmathi Institute of Pharmaceutical Science, Thimmapur, Karimnagar-505481, Andhra Pradesh, India
ABSTRACT Correspondence to Author: Mettu Srikanth Reddy Associate Professor, Jyothishmathi Institute of Pharmaceutical Sciences, Thimmapur, Karimnagar – 505481, Andhra Pradesh, India E-mail: srikanthreddymp@gmail.com
27 August, 2012
01 October, 2012
28 November, 2012
55. http://dx.doi.org/10.13040/IJPSR.0975-8232.3(12).4938-44
01 December, 2012
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