ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ATORVASTATIN CALCIUM AND UBIDECARENONE TABLET BY RP-HPLC
AbstractA reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and ubidecarenone in tablet formulation. The separation was achieved by 250×4.6 mm, 5µ, L-7 pack (peerless C-8) column and Methanol : Acetonitrile (80:20) as mobile phase, at a flow rate of 1.5 ml/min. The objective of this validation of an analytical procedure is to demonstrate that the drug Atorvastatin calcium and Ubidecarenone is suitable for its intended purpose. Developed method was found to be accurate, precise, selective, economical and rapid for simultaneous estimation of atorvastatin calcium and ubidecarenone in tablets.
Article Information
11
1679-1682
484
1687
English
Ijpsr
N. Kannappan, D. K. Sasidharan, P. Ramkumar, M. K. Prajapati* and P. P. Panda
Assistant Professor, Kashi Institute of Pharmacy, 23 Km. milestone - Allahabad road, Mirzamurad, Varanasi (Uttar Pradesh), India
24 March, 2011
29 April, 2011
26 June, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(7).1679-82
01 July, 2011
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