FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF LAMIVUDINE, ZIDOVUDINE AND NEVIRAPINE
AbstractThe present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of lamivudine and Zidovudine , Nevirapine- HAART triple therapy. The objective of this regimen is, To delay disease progression, To increase the duration of survival by achieving maximal and prolonged suppression of HIV replication, To restorate and preserve immunological function. Combination therapy is more effective and has less chances of developing resistance than monotherapy. To achieve this goal various prototype formulation trials were taken and evaluated with respect to the various quality control tests such as Thickness, hardness, weight variation, dissolution, disintegration, hardness and assay. The formula was finalized by comparing the Invitro dissolution profile with that of the Marketed Tablets. The in vitro release study was performed in 0.1N HCl upto 60 min. Among all the formulations, formulation F7 release profile was good as compared to the marketed products. Stability studies (40±2ºC/75±5%RH) for 2 months indicated that no characteristics changes in formulation. There was no chemical interaction between drug and excipients
Article Information
27
1772-1776
557
1193
English
Ijpsr
Srikanth Thota*, A. K. Radhalakshmi, D. Krishnanrajan and K. G. Parthiban
Department of Pharmaceutics, JKKMMRF College of Pharmacy, Komarapalayam, Tamil Nadu, India
07 April, 2011
07 May, 2011
27 June, 2011
2http://dx.doi.org/10.13040/IJPSR.0975-8232.2(7).1772-76
01 July, 2011
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