IMPROVED FUNCTIONALITY EXCIPIENTS FOR ORAL SOLID DOSAGE FORMS
AbstractOver the years, significant advances in the manufacturing processes of oral solid dosage forms have occurred, including the transition from tablet preparation by wet granulation to direct compression. The development of various added functionality excipients (AFEs), which are used to achieve formulations with desired end-effects, is equally important. The majority of excipients used in the manufacture of solid oral dosage forms have existed for the past two to three decades, many of them continue to be used today for large-scale tablet and capsule manufacturing. Excipients also influence the safety and effectiveness of drugs depending on the route of administration. The qualitative and quantitative understanding of the excipient’s composition is critically important to understand the bioavailability and bioequivalence of the dosage forms. In the case of orally administered dosage forms, excipients can affect safety and effectiveness outcomes by promoting or delaying gastrointestinal release.
Article Information
42
1673-1679
674
1756
English
Ijpsr
Nisha Mary Joseph*, Belay Biyena, s. Palani, and Anish Zacharia
School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
nisha_pharma@yahoo.com
17 August, 2014
25 November, 2014
30 December, 2014
10.13040/IJPSR.0975-8232.6(4).1673-79
01 April, 2015
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