DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF ABACAVIR AND ZIDOVUDINE TABLET IN COMBINATION

The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of Abacavir and Zidovudine tablet.  Combination of anti retiro-viral creates multiple obstacles to HIV replication to keep the number of off springs low,  reduce the possibility of superior mutations, decrease viral load and potentiate synergistic activity with one another, combining two drugs into one tablet reduces the number of individual medications¹. To achieve this goal various prototype formulation trials were taken with varying compositions of diluents and disintegrant and evaluated with respect to their various quality control tests such as Thickness, hardness, weight variation, dissolution, disintegration, hardness and assay. The formula was finalized by comparing the In-vitro dissolution profile of all formulations with the respective individual marketed products.  The in vitro release study was performed in 0.1N Hcl upto 60 min. Among all the formulations, formulation F6 release profile was good as compared to the other formulations. Forced degradation studies at 550C & Stability studies at 40±2ºC/75±5%RH (accelerated condition)  for 1& 3 months indicated that no characteristics changes in formulation. There was no chemical interaction between drugs and excipients.