DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFPODOXIME PROXETIL AND LEVOFLOXACIN HEMIHYDRATE IN COMBINED DOSAGE FORM
AbstractA simple, accurate, precise, rapid and economical RP-HPLC method was developed for the estimation of Cefpodoxime Proxetil (CPD) and Levofloxacin hemihydrate (LVX) in tablet dosage form. In Agilent – 1100/1200 Series, using C18 (250 x 4.6 mm x 5μ) column and with mobile phase composition of Phosphate buffer: Acetonitrile (pH 6.0) (50:50 v/v) at a flow rate of 1 ml/min was used. Detection was carried out at 240 nm. Retention time of CPD and LVX was found to be 5.64 & 5.97 min and 2.79 min, respectively. The method has been validated for linearity, accuracy and precision, LOD, LOQ and System suitability according to ICH Q2R1 Guideline
Article Information
22
3742-48
491
1207
English
IJPSR
Shuchi M. Desai *, Hitesh Dalwadi, Dhansukh Viradiya
ROFEL Shri G.M Bilakhia college of Pharmacy, Vapi, Gujarat, India
shuchi.desai89@gmail.com
09 April, 2016
12 August, 2016
21 August, 2016
10.13040/IJPSR.0975-8232.7(9).3742-48
01 September 2016
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