SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM FOR COMBINATION OF HYDROPHILIC AND LIPOPHILIC DRUGS
AbstractImprovement in the bioavailability of poorly soluble drugs is one of the challenges faced in the formulation development of the drugs. One of the most admirable and viable formulation approaches for this is self micro emulsifying drug delivery system (SMEDDS). A combination of clarithromycin and amoxicillin has been proved effective for treatment of H. pylori which are available only in tablet dosage form. Hence, the aim of the present study was to prepare SMEDDS of amoxicillin and clarithromycin for better patient compliance. SMEDDS were prepared using Peceol, Cremophor EL and Transcutol as oil, surfactant and co-surfactant respectively. Prepared SMEDDS were evaluated for particle size, zeta potential, water dispersion properties, saturation solubility and in-vitro drug release. Dilution study by visual observation showed that there was spontaneous micro emulsification and no sign of phase separation. Study concluded that SMEDDS can be an effective alternative for tablet therapy with enhanced dissolution rate and bioavailability.
Article Information
22
191-196
409
1356
English
IJPSR
Siya D. Sinai Kunde * and Shilpa P. Bhilegaonkar
Department of Pharmaceutics, PES’ Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa, India.
siya.kunde14@gmail.com
01 July, 2016
18 September, 2016
26 September, 2016
10.13040/IJPSR.0975-8232.8(1).191-96
01 January, 2017
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