DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC ASSAY METHOD FOR DETERMINATION OF LORNOXICAM IN SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) FORMULATION
AbstractThe objective of the present work was to development and validation of stability indicating RP-HPLC assay by applying different stress degradation conditions on lornoxicam in Self Emulsifying Drug Delivery System (SEDDS) formulation. HPLC separation was achieved on analytical technique using C-18 column and mobile phase of Acetonitrile: Methanol (65:35, v/v) at a UV detector. The lornoxicam drug consist in SEDDS formulation was subjected to acid, alkali, oxidation, dry heat and photo degradation treatment apply as stress degradation condition. The method was linear in the drug concentration range of 10-60 μg/ml with a correlation coefficient 0.999. The stress degradation studies showed that Lornoxicam contains in Self Emulsifying Drug Delivery System (SEDDS) formulation undergoes degradation in acid, alkali, oxidation and dry heat condition respectively within the limit as per ICH guidelines and stable in photo-degradation condition.
Article Information
60
2060-2065
655KB
1462
English
IJPSR
V.V. Chopade* and P.D. Chaudhari
Instutute of Pharmacy, National Institute of Medical Sciences (NIMS) University, Shobha Nagar, Jaipur-Delhi Highway, Jaipur – 303121, Rajasthan, India.
vitthalchopade@gmail.com
27 November, 2013
19 February, 2014
16 March, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2060-65
01, May 2014
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