ANTIDIABETIC ACTIVITY AND POTENTIAL MECHANISM OF MUKIA MADERASPATANA LINN. IN RATS INDUCED BY HIGH FAT DIET AND LOW DOSE STZ

To evaluate the anti-diabetic effects of the Mukia maderaspatana Linn. (MML), and to explore the possible mechanism. High-fat diet and STZ (35 mg/kg) induced diabetic rats were administered with MML at two dose levels (200 and 400 mg/kg/day, p.o.) for 21 days. Fasting blood glucose, lipid and lipoprotein levels such as triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and glucose tolerance were tested to evaluate its anti-diabetic effects. Moreover, the preliminary study of MML on the antioxidant activity was performed. The MML possessed anti-diabetic activities as shown by the decreased serum levels of fast blood glucose (FBG), TG, TC, LDL-C, and VLDL-C, as well as increased serum levels of HDL-C. MML also improved the oral glucose tolerance test (OGTT) to a certain degree. These benefits were also associated with increased catalase (CAT) superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in serum. The experimental results highlighted the hypoglycemic and hypolipidemic properties of the MML on diabetes and its complications, possibly through a strong antioxidant activity.