DEVELOPMENT AND EVALUATION OF ELASTIC NOISOMAL FORMULATION FOR MIGRAINE TREATMENT USING TRNA APPROACH

The approach of site specific topical delivery of Rizatriptan Benzoate (RBZ), used for migraine using the elastic carrier at posterior cervical region for sustained action was attempted in the present study. RBZ-entrapped elastic niosomes were prepared using the modified mechanical stirring method. The formulation was optimized using 2³ full factorial designs. The type of edge activator (EA), Tween: cholesterol: edge activator molar ratio (T:C:EA) and Total surfactant concentration (S) as independent and the percent entrapment efficiency (%EE) as dependent variables with visual stability of dispersion for two week as constrain factor for selection. The study revealed that interaction between EA and S was influencing factor for %EE. The optimized formulation EN3 having edge activator type, total surfactant concentration and molar ratio Tween 20: cholesterol: EA as Sodium cholate, 2% and 2:1:2 respectively, having high percent entrapment efficiency (92.22%), showed unilamellar smooth surface in SEM study. Zeta potential was found to be – 17.2 mV. In-vitro permeation from the elastic niosomal gel followed zero order model over a period of 12 h with non- Fickian diffusion mechanism. The biological anti-migraine test using acetic acid withering responses confirmed the sustained release of RBZ from Elastic niosome formulations.