RELATION OF INSULIN RESISTANCE AND BMI WITH SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS

Currently, coronary artery disease is reported as the major cause of mortality and morbidity and is expected to be the reason for 40% death in 2020. Since its rate is high in type 2 diabetes mellitus patients, a study has been designed to analyze the correlation of insulin resistance and obesity with incidence and severity of disease. Study was done on 109 individuals with established CAD in the age group of 40 – 70 years who had undergone coronary angiography and diagnosed with coronary artery disease including single vessel, double vessel and triple vessel and seventy one healthy individuals matched for age, and sex. The estimation of fasting FBG), post prandial blood glucose (PPBG, fasting insulin and insulin resistance by gold standard methods. In our study BMI and insulin resistance was found to be significantly high in CAD with diabetes mellitus subjects compared to CAD without DM and control (with p<0.001). Also in our study significantly high percentage of incidence of CAD and significantly high level of severity in CAD WDM patients with BMI >30 kg/m² was observed. Insulin resistance which is the major etiological factor of T2DM influence (affect) HDL, LDL and TG level which can increase the risk of CAD. The increase in IR leads to increased BMI as a part of dyslipidemia events.