FORMULATION AND EVALUATION OF RAMIPRIL LIQUISOLID COMPACT USING NOVEL CARRIER

The aim of the present investigation was to enhance the dissolution of poorly water-soluble drug Ramipril (BCS – II) drug through Liquisolid compact. The liquisolid compacts were prepared with a varied quantity of liquid and powder ingredients using microcrystalline cellulose as a carrier, Aerosil 200 as a coating material, polyethylene glycol 400, propylene glycol and tween-80 as liquid vehicles, HPMC as additives to increase loading capacity. The required quantities of ingredients for the compressible admixture were calculated using various mathematical models. The in-vitro release characteristics of different dissolution conditions were performed. All formulated systems were assessed for precompression parameters like flow properties, FTIR analysis, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and post-compression parameters like content uniformity, weight variation, hardness, friability, disintegration test, wetting time and in-vitro dissolution studies. As liquisolid compacts demonstrated significantly higher drug release rates, thereby indicating a promising strategy in improving the dissolution of poorly water-soluble drugs and formulating immediate release solid dosage forms.