IN-VIVO PHARMACOKINETIC EVALUATION OF PIOGLITAZONE – HPMC K 15 M FLOATING TABLETS
AbstractThe objective of the study is to make a pharmacokinetic evaluation of Pioglitazone floating tablets formulated employing HPMC K 15 M in comparison to Pioglitazone pure drug in rabbits. The two products were tested in a crossover RBD in healthy rabbits of either sex (n=6). The plasma concentrations of Pioglitazone were determined by a validated HPLC method. From the time versus plasma concentration data, various pharmacokinetic parameters (Cmax, Tmax, t1/2, AUC, Ka, and MRT) were calculated. Pioglitazone from the floating tablets formulated was absorbed slowly over longer periods in-vivo resulting in the maintenance of plasma concentrations within a narrow range over a longer period. The absorption rate constant (Ka) was decreased from 1.462 h-1 for Pioglitazone pure drug to 0.1598 h-1 with the floating tablets. MRT was increased from 9.82 h for Pioglitazone pure drug to 13.30 h with the floating tablets. There was no increase in the bioavailability of Pioglitazone from the floating tablets developed.
Article Information
29
1784-1786
534
795
English
IJPSR
G. C. Devi
University College of Pharmaceutical Sciences, Palamuru University, Bandameedipally, Mahabub Nagar, Telangana, India.
gchinnadevi@gmail.com
26 July 2018
01 October 2018
03 October 2018
10.13040/IJPSR.0975-8232.10(4).1784-86
01 April 2019
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