ANTIMICROBIAL RESISTANCE PATTERN OF ENTEROAGGREGATIVE ESCHERICHIA COLI ISOLATED FROM ACUTE DIARRHEA OF PEDIATRIC PATIENT UNDER FIVE IN KANPUR REGION

Enteroaggregative Escherichia coli (EAEC) strains are causal agents of persistent diarrhea in developing countries. Enteroaggregative Escherichia coli strains (EAEC) are an emerging type of diarrheagenic E. coli. We aimed to isolate, identify and characterize the E. coli pathotypes and study their antibiotic resistance in children under five with diarrhea in Kanpur region, India. Children under 5 years suffering from acute diarrhea and attending an outpatient clinic or admitted in Rama Hospital, Kanpur were enrolled for the study. Severe diarrhea is a public health problem and is responsible for morbidity and mortality, especially in developing countries. DEC was detected by multiplex PCR. Among 38 E. coli isolates, 12 samples contain Cvd432 gene of EAEC diarrheagenic E. coli. Most of the strains are resistant to ampicillin, Co-trimoxazole, gentamicin, azithromycin, imipenem. Ciprofloxacin, Norflex and chloramphenicol are relatively more sensitive. The high antimicrobial resistance observed in our study raises a broad discussion on the indiscriminate or improper use of antimicrobials, besides the risks of self-medication.