GEOGRAPHICAL BASED GENOMIC AND PATHOGENIC STUDY OF THE SARS-COV-2
AbstractThe current pandemic COVID 19 caused by SARS-CoV-2 is very contagious and causes respiratory disease. Genomic analysis of different strains in SARS-CoV-2 were found to infect different geographical locations of the world (India, USA, and Brazil) and also in different parts of India (Kerala, Surat, and Ahmedabad). These sequences were downloaded from the viral genome sequence database of the National Center for Biotechnology Information (NCBI), and comparative analysis is performed using various computational tools. Comparison of genome size, G+C content, and identified ORFs is performed for different sequences of SARS-CoV-2 isolated from different geographical locations of the world and also from different cities/states of India using various bioinformatics tools. This study concludes that all the sequences isolated from different geographical locations are highly similar to the reference strain of Wuhan, with an identity percentage ranging from 99.56-99.98% and also with the same GC content of 37%. The difference in the identified ORFs of length >150 and a small difference in the identity percentages shows the presence of mutation between different strains of SARS-CoV-2.
Article Information
61
2411-2416
660
563
English
IJPSR
G. Dhanalakshmi * and Anadi
Department of Biochemistry, Padmashree Institute of Management and Sciences, Bangalore, Karnataka, India.
dhanu.bio@gmail.com
30 December 2020
25 February 2021
16 March 2021
10.13040/IJPSR.0975-8232.12(4).2411-16
01 April 2021
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