A NEW RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TOLCAPONE AND QUINAPRIL IN ITS PURE AND PHARMACEUTICAL DOSAGE FORM
AbstractA short selective, precise, accurate, and sensitive method for the estimation of Tolcapone and Quinapril was done by RP-HPLC. The assay of Tolcapone and Quinapril was performed with tablets, and the % assay was found to be 100.19 and 100.45, which shows that the method is useful for routine analysis. The linearity of Tolcapone and Quinapril was found to be linear with a correlation coefficient of 0.999 and 0.999, which shows that the method is capable of producing good sensitivity. The acceptance criteria of precision percent RSD should be not more than 2.0%, and the method show precision 0.2 and 0.7 for Tolcapone and Quinapril, which shows that the method is precise. The acceptance criteria of intermediate precision are RSD should be not more than 2.0%, and the method show precision 0.3 and 0.7 for Tolcapone and Quinapril, which shows that the method is repeatable when performed in different days also. The LOD and LOQ for Tolcapone were found to be 3.07 and 9.98, and LOD and LOQ for Quinapril were found to be 2.95 and 10.00. Therefore, this method can be adopted to estimate Tolcapone as well as Quinapril in other pharmaceutical formulations.
Article Information
44
3375-3380
793
477
English
IJPSR
A. K. Begum * and S. Mubashir
Department of Pharmaceutical Analysis, Shadan Women’s College of Pharmacy, Khairatabad, Hyderabad, Telangana, India.
ayeshabegumk@mail.com
17 June 2020
08 December 2020
04 May 2021
10.13040/IJPSR.0975-8232.12(6).3375-80
01 June 2021
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