TECHNOLOGICAL DEVELOPMENT IN COMPARISON WITH IDEAL FORMULATION OF BCS CLASS IV DRUG – RIFAXIMIN
AbstractThe solubility, dissolution, and gastrointestinal permeability are the prime factors for drug absorption. Rifaximin is a structural analogue of rifamycin that inhibits RNA synthesis by binding to β-subunit of bacterial DNA-dependent RNA polymerase. Rifaximin is a class 1V drug having low solubility and low permeability. My theme of the design is to develop the technological characterization of dosage by converting the drug into nanoparticles and superdisintegrant technology; the drug undergoes solubility and gastrointestinal permeability. By adopting these technologies, it achieves by enhancing the disintegration time of drug when comes in contact with water. Here I would like to promote the range of method development technologies improving the solubility and permeability of class IV drugs in rifaximin.
Article Information
31
4331-4340
899
650
English
IJPSR
A. D. Paul and P. R. Sri *
Department of Pharmaceutics, Sri Venkateswara University College of Pharmaceutical Sciences, Tirupati, Andhra Pradesh, India.
peyyalaramyasri9@gmail.com
23 August 2020
17 March 2021
17 May 2021
10.13040/IJPSR.0975-8232.12(8).4331-40
01 August 2021
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