FORMULATION AND EVALUATION OF DICLOFENAC SODIUM MICROEMULSION SUBCUTANEOUS DRUG DELIVERY SYSTEM
AbstractThe objective of this current work is to develop the formulation and evaluation of a subcutaneous drug delivery system based on diclofenac sodium microemulsion. A different formulation has been formulated using a modifying amount of gelling agent and a penetration enhancer. Pseudo ternary phase diagrams were constructed for different microemulsion formulations composed of the formulations FEG1, FEG2, and FEG3 manufactured by Carbopol 934 and FEG4, FEG5, and FEG6 by Xanthan gum, and the formulations FEG7, FEG8, and FEG9 were prepared by HPMCK15M as a dispersion phase. The formulation was an evaluation for physicochemical properties of drug and polymers, rheological studies, In-vitro drug release studies, Zero-order, and first-order release kinetics studies. The in-vitro release of the microemulsion drug was greater than the commercialized formulation. The Hind paw method (Acute inflammatory model) test was performed in rate to evaluate the analgesic activity of fabricated emulgel. The overall findings of this study suggest that the developed emulgel formulation of diclofenac sodium can be used potential approach for the management of analgesic effect.
Article Information
42
4418-4428
1018
1114
English
IJPSR
N. Khan, V. C. Bala *, H. Singh and R. Jayant
Department of Pharmacology, Oxford College of Pharmacy, Ghaziabad, Uttar Pradesh, India.
vidhanchandbala07@gmail.com
28 August 2020
26 January 2021
19 May 2021
10.13040/IJPSR.0975-8232.12(8).4418-28
01 August 2021
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