DEVELOPMENT AND VALIDATION OF SPECTROSCOPIC METHODS FOR THE SIMULTANEOUS ESTIMATION OF RASAGILINE AND RILUZOLE
AbstractIn the present study, an effort has been made to estimate Rasagiline and Riluzole simultaneously in their bulk and physical mixture by UV-Visible spectrophotometric methods. The methods developed are precise, reliable simultaneous equations and area under the curve (AUC) method. The absorption maxima in the simultaneous equation method are 265.20 nm and 263.40 nm, respectively, for rasagiline and riluzole. Similarly, in the area under the curve method, the wavelength selected for estimation is in the range of 260.20 – 270.20 nm and 258.40-268.40 nm, respectively for rasagiline and riluzole. In the two methods developed, the Beer- Lambartz’s range was in the concentration range of 50 to 250 µg/mL for rasagiline and 4 to 20µg/mL for riluzole. The percentage recovery was found to be in the range of 100.43% and 100.01% for rasagiline and riluzole. ICH guidelines were followed in the proposed methods for their reproducibility and accuracy. The proposed methods can be adopted industrially and in research laboratories for the routine simultaneous analysis of Rasagaline and Riluzole in their bulk and dosage forms.
Article Information
44
6028-6036
677 KB
471
English
IJPSR
Ramgopal Dhanwad, Deepali, L. Harini and K. C. Chaluvaraju *
Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Bengaluru, Karnataka, India.
chaluvarajukc@gmail.com
03 January 2021
09 April 2021
26 May 2021
10.13040/IJPSR.0975-8232.12(11).6028-36
01 November 2021
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