FORMULATION AND EVALUATION OF ORAL ANTI-DIABETIC IN-SITU GEL SYSTEM OF PIOGLITAZONE
AbstractPioglitazone is an oral anti-diabetic agent used in treating class – II diabetes mellitus. T1/2of pioglitazone was 3-6 hrs and is eliminated rapidly. Hence sustained release is needed to prolong its duration of action and to increase its oral bioavailability. The study’s main aim was formulation and evaluation of an in-situ gel system of pioglitazone to increase its bioavailability as a convenient dosage form. Method of Ion-sensitive in-situ gelation was used in this study. Total 15 formulations were prepared with Guar gum, Xanthan gum, and Carbopol-934 in various combinations and assessed for physical appearance, pH, viscosity, in-vitro gelling capacity, drug content, and in-vitro drug release. FTIR, DSC for Pioglitazone, excipients, and optimized formulation were conducted. In-vivo drug kinetic studies were conducted for optimized formulation. Formulations showed an optimum viscosity allowing ease of administration and swallowing. All formulations have shown pH between 6.9-7.3, floating lag time was 2-3sec and floated for >12 hrs. The x-ray image studies are also confirming the same thing. In vitro, drug release studies report that F15 shows drug release of 99.52% over 12 hours. FTIR studies revealed no interaction between drugs and excipients used. The results of In-vivo kinetic studies approve the better performance of the optimized formulation. In conclusion, the optimized formulation F15 showed maximum drug retardation for above 12 h. Hence, it is concluding that the study’s main objective to increase its bioavailability as a convenient dosage form in the treatment of diabetes mellitus had been achieved.
Article Information
42
375-383
1027 KB
518
English
IJPSR
B. Padmasri * and R. Nagaraju
Department of Pharmaceutical Technology, Sri Venkateswara College of Pharmacy, Etherla, Srikakulam, Andhra Pradesh, India.
padmasripharma@gmail.com
21 March 2021
22 May 2021
05 December 2021
10.13040/IJPSR.0975-8232.13(1).375-83
01 January 2022