PREPARATION AND IN-VITRO EVALUATION OF 0.05% 5-FLUOROURACIL SOLID LIPID NANOPARTICLE GEL IN THE TREATMENT OF ACTINIC KERATOSIS
AbstractThe present study focused on the formulation and in-vitro evaluation of 0.05% 5-fluorouracil solid lipid nanoparticle gel in treating actinic keratosis. The in-vitro release profile of solid lipid nanoparticle gel is higher than the marketed cream formulation; thus, we can reduce the dose of formulation by this method. This is prepared using tween 80, tween 20, glycerol monostearate, glycerol, and lecithin. Pre-formulation studies for the pure drug were conducted, and formulations were evaluated based on viscosity, encapsulation efficiency and in-vitro drug release study using franz diffusion cell. FTIR study of pure drug-polymer and formulation proves there is no chemical interaction between them. Formulation SLN2 had appropriate viscosity of 1738.34, the highest encapsulation efficiency of 94.45%, drug loading 31.97%. SLN2 shows 95% cell viability. The in-vitro release study was found to have a zero-order release profile. Compared to all other formulations, this indicates the predominant mechanism of drug release is diffusion.
Article Information
32
1726-1737
913 KB
396
English
IJPSR
B. Aswathy *, Remya Ravindran, R. P. Ramkumar and Labeeb Apaduvanpadavath
Department of Pharmaceutics, KTN College of Pharmacy, Chalavara, Kerala, India.
aswathynbalan@gmail.com
28 July 2021
03 September 2021
09 September 2021
10.13040/IJPSR.0975-8232.13(4).1726-37
01 April 2022
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