CHITOSAN CO-CRYSTAL FOR ENHANCING THE SOLUBITY AND DISSOLUTION RATE OF DICLOFENAC SODIUM
AbstractThe present study is designed to enhance the aqueous solubility of diclofenac sodium. For the said purpose co-crystal employing chitosan with diclofenac sodium is prepared by solvent exchange. The prepared co-crystal was characterized by FTIR, DSC, XRD and TGA studies. Further, solubility, anti-inflammatory activity and in-vitro release study was determined for different batches of the formulation. The solubility of different bathes of co-crystal was found to be between 34.6 to 46.6µg/ml as compared to the pure drug having a solubility of 18.6 and a physical mixture of 30.9µg/ml. The in-vitro release is found to be 72.5 to 84.8%, whereas PM shows 58.7 % release and pure drug shows 27.8 % release. The in-vitro release data of the optimized batch followed fickian diffusion mechanism. The % inhibition of formulation co-crystal is much more than the model drug (diclofenac sodium). Thus, the diclofenac-loaded co-crystal would be useful for delivering poorly water-soluble drugs with enhanced dissolution, solubility and improved anti-inflammatory activity of the drug.
Article Information
33
357-365
1552 KB
456
English
IJPSR
Sunita Devi *, Kavita Bahmani and Rinkle
Departmental of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.
sunitamechu1504@gmail.com
28 July 2020
06 December 2022
19 December 2022
10.13040/IJPSR.0975-8232.14(1).357-65
01 January 2023
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