DESIGN, DEVELOPMENT AND EVALUATION OF STABLE VALSARTAN NANOCRYSTALS WITH CHITOSAN USING MICROWAVE-ASSISTED GRINDING NANOTECHNOLOGY

Solubility and stability are the limiting steps for almost all drugs in the pharmaceutical field toward bioavailability. In the present investigation, microwave reacts with the crystallization solvent to change their crystalline state to stable and highly soluble nanocrystals. Microwave Assisted Grinding Nanotechnology (MAGN) was used to prepare stable nanocrystals of Valsartan, BCS class II, by treating them with Chitosan and neusiline US2. Ternary crystalline particles were designed using 3² level full factorial design using Design Expert Software version 12. The optimized batch showed a nano-size range with about a 3.2 times increase in saturation solubility and 2.89 times enhanced cumulative drug release than pure valsartan. Compatibility with excipients, crystallinity and particle size study was confirmed from FTIR, DSC, XRD, and particle analyzer. Physical interactions from FTIR and NMR results also confirmed intermolecular hydrogen bond interaction. The accelerated stability study showed a confirmed stable product due to the absence in any interactions from FTIR and variation of drug content. Formulation of microwave-treated nanocrystals is a novel technique to enhance bioavailability with improved solubility and stability.